The musical stars David Fynn as the drop out rocker who impersonates his best friend in order to get a job in a school, where he puts together a band from the students.
Patricia Hodge, Rebekah Brooks, Stiles and Drewe and Amanda Abbington were among the guests at the opening.
Sarah Crompton reviewed the show for WhatsOnStage, giving it four stars and saying: "You'd need a heart of stone not to melt at its sheer joy."
School of Rock - The Musical runs at the New London Theatre until 12 February.
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